Thus, the enhancement of temporal beta2-band oscillations represents a signature for AHs in both patients and a monkey model of psychosis, and this monkey model can be used for developing closed-loop neuromodulation approaches for the treatment of refractory AHs in schizophrenia.Īuditory hallucinations Electroencephalography Methamphetamine Non-human primate Schizophrenia. ![]() Epidural EEG beta2-band power in the temporal region of these monkeys was enhanced immediately after methamphetamine treatment and positively correlated with the frequency of sudden searching actions. We further generated methamphetamine-treated rhesus monkeys exhibiting psychosis-like behaviors, including repetitive sudden searching actions in the absence of external intrusion, suggesting the occurrence of AHs. During the period of AHs, EEG recordings exhibited significantly elevated beta2-band power in the temporal region, as compared to those recorded in the absence of AHs or during stimulation with verbal sounds. We recorded EEG from 25 schizophrenia patients with recurrent AHs. electroencephalographic (EEG) signature of auditory hallucinations (AHs) is important for facilitating the diagnosis and treatment of AHs in schizophrenia. 15 Shanghai Quanlan Technology Co., Ltd, Shanghai, 201602, China. 14 Shanghai Center for Brain Science and Brain-inspired Technology, Lingang Laboratory, Shanghai, 201602, China. 13 Department of Neurosurgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200020, China. ![]() 12 Institute of Psychological and Behavioral Science, Shanghai Jiao Tong University, Shanghai, 200030, China. ![]() 11 Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, China. 10 Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, CAS Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai, 200031, China.
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